Selected Publications

i-bodies

• Lynch JP, Organ L, Tomusange K, Kowalczyk L, Hartman DJ, Tester A, Hosking C and Foley M. (2025) AD-214 anti CXCR4 i-body-Fc fusion for the treatment of idiopathic pulmonary fibrosis. MABS https://doi.org/10.1080/19420862.2025.2505090

• Angage, D., Chmielewski, J., Maddumage, J.C. et al. A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites. Nat Commun 15, 7206 (2024). https://doi.org/10.1038/s41467-024-50770-7

• Cao Q, Foley M, Gill AJ, Chou A, Chen X and Pollock CA. (2024) Second generation i-body AD-214 attenuates unilateral ureteral obstruction (UUO)-induced kidney fibrosis through inhibiting leukocyte infiltration and macrophage migration. Int. J. Mol. Sci. 25,13127 https://doi.org/10.3390/ijms252313127

• Qiu H, Hosking C, Samantha A, Chen K, Kuek V, Vrielink A, Lim K, Foley M, Xu J (2023) ADR3, a next generation i-body to human RANKL, inhibits osteoclast formation and bone resorption. J. Biol. Chem. 299;2 https://doi.org/10.1016/j.jbc.2023.102889

• Griffiths K, Binder U, McDowell W, Tommasi R, Frigerio M, Darby WG, Hosking CG, Renaud L, Machacek M, Lloyd P, Skerra A, Foley M. Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4. MAbs. 2019 Oct;11(7):1331-1340. doi: 10.1080/19420862.2019.1626652. Epub 2019 Aug 23. PMID: 31156041; PMCID: PMC6748587.

• Griffiths K, Dolezal O, Cao B, Nilsson SK, See HB, Pfleger KDG, Roche M, Gorry PR, Pow A, Viduka K, Lim K, Lu BGC, Chang DHC, Murray-Rust T, Kvansakul M, Perugini MA, Dogovski C, Doerflinger M, Zhang Y, Parisi K, Casey JL, Nuttall SD, Foley M. i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4. J Biol Chem. 2016 Jun 10;291(24):12641-12657. doi: 10.1074/jbc.M116.721050. Epub 2016 Apr 1. PMID: 27036939; PMCID: PMC4933451.

IgNARS

• Qiu H, Hosking C, Samantha A, Chen K, Kuek V, Vrielink A, Lim K, Foley M, Xu J (2023) ADR3, a next generation i-body to human RANKL, inhibits osteoclast formation and bone resorption. J. Biol. Chem. 299;2 https://doi.org/10.1016/j.jbc.2023.102889

• D.P. Simmons V.A Streltsov, O. Dolezal, P. J. Hudson, A. M Coley, M FOLEY, D. F. Proll and S. D. Nuttall. (2008) Shark IgNAR Antibody Mimotopes Target a Murine Immunoglobulin through Extended CDR3 Loop Structures. PROTEINS: Structure, Function, and Bioinformatics. 71, 119-30.

Peptides

• Harris KS, Casey JL, Coley AM, Karas JA, Sabo JK, Tan YY, Dolezal O, Norton RS, Hughes AB, Scanlon D, FOLEY M. (2009) Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning. Journal of Biological Chemistry. 284, 9361-71.

• Li F, Dluzewski A, Coley AM, Thomas A, Tilley L, Anders RF, FOLEY M. (2002) Phage-displayed peptides bind to the malarial protein apical membrane antigen-1 and inhibit the merozoite invasion of host erythrocytes. J Biol Chem. 277, 50303-10